Targeting of genes to the liver with glycoprotein carriers
Identifieur interne : 002C09 ( Main/Exploration ); précédent : 002C08; suivant : 002C10Targeting of genes to the liver with glycoprotein carriers
Auteurs : John Frese Jr. [États-Unis] ; Catherine H. Wu [États-Unis] ; George Y. Wu [États-Unis]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 1994.
English descriptors
- Teeft :
- Acad, Adenovirus, Antisense, Asialoglycoprotein, Asialoglycoprotein receptor, Asor, Biol, Cationic liposomes, Cell biol, Cell lines, Chem, Chloramphenicol, Chloramphenicol acetyltransferase, Complexed, Complexed antisense, Drug delivery reviews, Endocytosis, Folinic acid, Foreign gene, Foreign gene expression, Foreign genes, Frese, Gene, Gene delivery, Gene expression, Gene therapy, Gene transfer, Hepatectomy, Hepatocytes, Hepatoma, Hepatoma cells, Hepg2, Hepg2 cells, Human hepatoma cells, Ligand, Liposome, Liver cells, Liver diseases, Liver homogenates, Mouse lung, Natl, Normal hepatocytes, Other investigators, Partial hepatectomy, Persistent expression, Plasmid, Polycation, Proc, Protective agents, Receptor, Significant decrease, Transfection, Transferrin, Transferrin receptor, Transferrin receptors, Viral, Vivo.
Abstract
Abstract: Several techniques are available to deliver foreign genes to cells in vitro. These techniques have offered valuable insights into gene regulation and expression. Many of these methods, however, have limited in vivo potential for clinical gene therapy because they compromise cell viability or cannot be targeted to desired cell types. Strategies with high potential for use in gene therapy need to satisfy several criteria: (1) use of a stable vector for the foreign DNA, (2) efficient expression of foreign DNA in host cells, and (3) a means to target a desired cell type or organ. Hepatocytes are attractive targets for gene therapy because of their large number, rich blood supply and important role in intermediary metabolism. Hepatocytes have also been found to have specific cell surface receptors that can be utilized for targeted delivery of foreign DNA.This article discusses in vitro and in vivo methods of targeted delivery and expression of foreign genes in hepatocytes with emphasis on those techniques with potential for clinical gene therapy. Methods to enhance and prolong foreign gene expression such as the use of the lysosomotropic agent chloroquine, endosomal disruption by adenovirus and influenza virus hemagglutinin HA-2 subunit, and partial hepatectomy, which has been found to augment foreign gene expression, are covered. Finally, the use of ligand-based systems to target sense and antisense DNA in gene therapy to correct metabolic disorders and the targeted delivery of protective agents to the liver are addressed.
Url:
DOI: 10.1016/0169-409X(94)90009-4
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C91
- to stream Istex, to step Curation: 001C91
- to stream Istex, to step Checkpoint: 001992
- to stream Main, to step Merge: 002C69
- to stream Main, to step Curation: 002C09
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Targeting of genes to the liver with glycoprotein carriers</title>
<author><name sortKey="Frese Jr, John" sort="Frese Jr, John" uniqKey="Frese Jr J" first="John" last="Frese Jr.">John Frese Jr.</name>
</author>
<author><name sortKey="Wu, Catherine H" sort="Wu, Catherine H" uniqKey="Wu C" first="Catherine H." last="Wu">Catherine H. Wu</name>
</author>
<author><name sortKey="Wu, George Y" sort="Wu, George Y" uniqKey="Wu G" first="George Y." last="Wu">George Y. Wu</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9B545D95AEF5B0B34FC846A3A4B68A5544D82C73</idno>
<date when="1994" year="1994">1994</date>
<idno type="doi">10.1016/0169-409X(94)90009-4</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-JXFZ0JGB-B/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001C91</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C91</idno>
<idno type="wicri:Area/Istex/Curation">001C91</idno>
<idno type="wicri:Area/Istex/Checkpoint">001992</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001992</idno>
<idno type="wicri:doubleKey">0169-409X:1994:Frese Jr J:targeting:of:genes</idno>
<idno type="wicri:Area/Main/Merge">002C69</idno>
<idno type="wicri:Area/Main/Curation">002C09</idno>
<idno type="wicri:Area/Main/Exploration">002C09</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Targeting of genes to the liver with glycoprotein carriers</title>
<author><name sortKey="Frese Jr, John" sort="Frese Jr, John" uniqKey="Frese Jr J" first="John" last="Frese Jr.">John Frese Jr.</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut School of Medicine, Farmington, CT 06001</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Catherine H" sort="Wu, Catherine H" uniqKey="Wu C" first="Catherine H." last="Wu">Catherine H. Wu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut School of Medicine, Farmington, CT 06001</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, George Y" sort="Wu, George Y" uniqKey="Wu G" first="George Y." last="Wu">George Y. Wu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut School of Medicine, Farmington, CT 06001</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Advanced Drug Delivery Reviews</title>
<title level="j" type="abbrev">ADR</title>
<idno type="ISSN">0169-409X</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1994">1994</date>
<biblScope unit="volume">14</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="137">137</biblScope>
<biblScope unit="page" to="152">152</biblScope>
</imprint>
<idno type="ISSN">0169-409X</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0169-409X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term>
<term>Adenovirus</term>
<term>Antisense</term>
<term>Asialoglycoprotein</term>
<term>Asialoglycoprotein receptor</term>
<term>Asor</term>
<term>Biol</term>
<term>Cationic liposomes</term>
<term>Cell biol</term>
<term>Cell lines</term>
<term>Chem</term>
<term>Chloramphenicol</term>
<term>Chloramphenicol acetyltransferase</term>
<term>Complexed</term>
<term>Complexed antisense</term>
<term>Drug delivery reviews</term>
<term>Endocytosis</term>
<term>Folinic acid</term>
<term>Foreign gene</term>
<term>Foreign gene expression</term>
<term>Foreign genes</term>
<term>Frese</term>
<term>Gene</term>
<term>Gene delivery</term>
<term>Gene expression</term>
<term>Gene therapy</term>
<term>Gene transfer</term>
<term>Hepatectomy</term>
<term>Hepatocytes</term>
<term>Hepatoma</term>
<term>Hepatoma cells</term>
<term>Hepg2</term>
<term>Hepg2 cells</term>
<term>Human hepatoma cells</term>
<term>Ligand</term>
<term>Liposome</term>
<term>Liver cells</term>
<term>Liver diseases</term>
<term>Liver homogenates</term>
<term>Mouse lung</term>
<term>Natl</term>
<term>Normal hepatocytes</term>
<term>Other investigators</term>
<term>Partial hepatectomy</term>
<term>Persistent expression</term>
<term>Plasmid</term>
<term>Polycation</term>
<term>Proc</term>
<term>Protective agents</term>
<term>Receptor</term>
<term>Significant decrease</term>
<term>Transfection</term>
<term>Transferrin</term>
<term>Transferrin receptor</term>
<term>Transferrin receptors</term>
<term>Viral</term>
<term>Vivo</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Several techniques are available to deliver foreign genes to cells in vitro. These techniques have offered valuable insights into gene regulation and expression. Many of these methods, however, have limited in vivo potential for clinical gene therapy because they compromise cell viability or cannot be targeted to desired cell types. Strategies with high potential for use in gene therapy need to satisfy several criteria: (1) use of a stable vector for the foreign DNA, (2) efficient expression of foreign DNA in host cells, and (3) a means to target a desired cell type or organ. Hepatocytes are attractive targets for gene therapy because of their large number, rich blood supply and important role in intermediary metabolism. Hepatocytes have also been found to have specific cell surface receptors that can be utilized for targeted delivery of foreign DNA.This article discusses in vitro and in vivo methods of targeted delivery and expression of foreign genes in hepatocytes with emphasis on those techniques with potential for clinical gene therapy. Methods to enhance and prolong foreign gene expression such as the use of the lysosomotropic agent chloroquine, endosomal disruption by adenovirus and influenza virus hemagglutinin HA-2 subunit, and partial hepatectomy, which has been found to augment foreign gene expression, are covered. Finally, the use of ligand-based systems to target sense and antisense DNA in gene therapy to correct metabolic disorders and the targeted delivery of protective agents to the liver are addressed.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Connecticut</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Frese Jr, John" sort="Frese Jr, John" uniqKey="Frese Jr J" first="John" last="Frese Jr.">John Frese Jr.</name>
</region>
<name sortKey="Wu, Catherine H" sort="Wu, Catherine H" uniqKey="Wu C" first="Catherine H." last="Wu">Catherine H. Wu</name>
<name sortKey="Wu, George Y" sort="Wu, George Y" uniqKey="Wu G" first="George Y." last="Wu">George Y. Wu</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:9B545D95AEF5B0B34FC846A3A4B68A5544D82C73 |texte= Targeting of genes to the liver with glycoprotein carriers }}
This area was generated with Dilib version V0.6.33. |